| 1. | long-term treatment and evidence of their effectiveness in acute bipolar depression is limited. They appear to pose greater risk ... depression but less evidence supports efficacy and safety in acute bipolar depression. Depressive episodes predominate in bipolar disorder with chronic ... |
| 2. | received adjunctive EPA 6 grams/d or placebo. One study enrolled 59 patients with acute bipolar depression; ... 4 months 6 grams/d of EPA in patients with acute bipolar depression 59 No significant difference in mean change from baseline ... |
| 3. | summarize findings from randomized controlled studies that have examined antidepressants’ efficacy for acute bipolar depression. Except for a study of fluoxetine plus olanzapine ... |
| 4. | Similarly studies of topiramate’s potential efficacy in acute bipolar depression and as a maintenance treatment are needed. ... has not been formally tested as a treatment for acute bipolar depression. So while oxcarbazepine is an attractive alternative ... |
| 5. | had funded little work on prophylaxis of bipolar disorders or acute bipolar depression. Following two NIMH conferences on bipolar illness ... |
| 6. | Quetiapine and the combination olanzapine/fluoxetine are FDA-approved for acute bipolar depression episodes but not all atypical antipsychotics show antidepressant effects ... Lamotrigine’s benefit in acute bipolar depression is controversial as no trial has shown unequivocally that it is more effective than placebo. ... |
| 7. | The relationship between serum valproate and therapeutic efficacy in acute bipolar depression—and the range of levels considered therapeutic—are undefined. For now we recommend that individual patients’ clinical response and tolerability guide optimum serum valproate in acute bipolar depression (Box) ... |
| 8. | 15 Lamotrigine also has demonstrated efficacy as add-on treatment to lithium for acute bipolar depression.16 In 2 identical 8-week placebo-controlled ... |
| 9. | more at-risk populations. Also efficacy shown in acute bipolar depression for 8 weeks in RCTs cannot legitimately be translated ... |
| 10. | harmful because of the risk of inducing mania. For acute bipolar depression adjunctive antidepressant treatment has been found to be no ... When 64 patients with acute bipolar depression received both antidepressants and mood stabilizers in a randomized double-blind trial switch rates ... |