| 1. | Clinicians need effective regimens for treatment-resistant schizophrenia and mood-stabilizer augmentation helps some patients. ... 19 20 Adjunctive lamotrigine may be effective in managing treatment-resistant schizophrenia as was shown in a small (n = 34) ... |
| 2. | treatment-resistant schizophrenia Treatment-resistant schizophrenia is defined as residual positive symptoms after ≥2 adequate antipsychotic trials. ... treatment-resistant schizophrenia patients especially those on clozapine. Could lamotrigine augmentation be of benefit only in treatment-resistant schizophrenia? ... |
| 3. | Even so these numbers seem to indicate that combination therapy is not unsafe for patients with treatment-resistant schizophrenia (Box). ... Box Defining treatment-resistant schizophrenia Most trials have used criteriafrom the seminal clozapine study to define “treatment resistant” schizophrenia: ... |
| 4. | Harrison G. Pope Jr MD; Gen Kanayama MD PhD Treatment-resistant schizophrenia: What role for mood stabilizers? ... |
| 5. | 13 14 Other options will likely develop for augmenting antipsychotic therapy for treatment-resistant schizophrenia but none are available and supported by adequate data ... Tiihonen J Hallikainen T Ryynänen OP et al. Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial. ... |
| 6. | I am reminded of this aphorism by Dr. Leslie Citrome’s article “Treatment-resistant schizophrenia: What role for mood stabilizers?”. ... |
| 7. | The authors’ observations Substantial evidence supports clozapine’s efficacy in treatment-resistant schizophrenia and this second-generation antipsychotic (SGA) also might reduce suicidality. ... switch to an antidepressant or add a mood stabilizer for treatment-resistant schizophrenia 3 but little evidence supports these options. ... |
| 8. | These mixed findings on high-dose olanzapine suggest questionable efficacy in patients with treatment-resistant schizophrenia and an uncertain risk of increased toxicity. ... Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: A review and meta-analysis of randomized trials. ... |
| 9. | Kane JM Honigfeld G Singer J et al. Clozapine for the treatment-resistant schizophrenia: a double-blind comparison with chlorpromazine. ... |
| 10. | comparing clozapine with other SGAs in 136 patients with treatment-resistant schizophrenia Found clozapine significantly more effective (P<0.02 ... Clozapine remains the most effective antipsychotic for patients with treatment-resistant schizophrenia Long-acting antipsychotics by promoting adherence may improve patient outcomes ... |
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